Mechanism of action
The physiologic mechanism of erection of the penis involves release of nitric oxide (NO) in the corpus cavernosum during sexual stimulation. NO then activates the enzyme guanylate cyclase, which results in increased levels of cyclic guanosine monophosphate (cGMP), producing smooth muscle relaxation in the corpus cavernosum and allowing inflow of blood. Sildenafil has no direct relaxant effect on isolated human corpus cavernosum, but enhances the effect of nitric oxide (NO) by inhibiting phosphodiesterase type 5 (PDE5), which is responsible for degradation of cGMP in the corpus cavernosum.
When sexual stimulation causes local release of NO, inhibition of PDE5 by sildenafil causes increased levels of cGMP in the corpus cavernosum, resulting in smooth muscle relaxation and inflow of blood to the corpus cavernosum. Sildenafil at recommended doses has no effect in the absence of sexual stimulation.
Indications :
It is indicated for the management of erectile dysfunction.
Side effects :
There are mild side effects experienced from this drug, which can be covered by intake more and more water. Some of the side effects are
- faintness
- Facial flushing
- Sudden hearing loss
- Giddiness
- Pain in chest
- Difficulty in breathing
- unclear vision
- Irregular heartbeat
- Painful penile erection
Advantages
If you are facing problems in your sexual life, then you should consider the utilization of these tablets which is considered the most useful medication for getting rid of these problems. It would help in making the muscles relaxed of penis, which further helps in providing prolonged and satisfactory erection.
Dosage
For the use of this drug, a doctor should be consulted and according to their suggestion, it should be consumed. These tablets are manufactured in different dosages starting from 25 mg, 50 mg to 100 mg. According to the doctor’s advice, the dose should be limited to 1 tablet per day whereas in case of missed dose, it is important to make sure that you do not consume more than one in a day.
Storage:
Store at room temperature. Protect from high temperature, light and dampness. Keep away from reach of children.
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